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Medicines are responsible for more than a third of the improvement in life expectancy from 1990 to 2015, according to a recent study published in Health Affairs. This underscores the crucial role of biopharmaceutical innovation, as life expectancy increased 3.3 years during that time period.

For all causes of death, public health interventions were accountable for 44% of improved life expectancy, while pharmaceuticals were the second-leading cause of gains in life years at 35%. Notably, improvements in treatment thanks to biopharmaceutical innovation accounted for the majority of mortality changes in several disease areas:

  • 76% of improvements in mortality for patients with HIV

  • 60% of improvements in mortality for patients with breast cancer

  • 52% of improvements in mortality for patients with heart disease

Catalyst_LTAC_LifeExpectancy_WOLogo

Medicines are this country’s best chance at tackling the biggest health care cost driver: chronic disease. Chronic health conditions, such as cancer, diabetes and heart disease, are the leading causes of death and disability in the United States and account for about 90% of health care spending.

Thanks largely to constant biopharmaceutical innovation, many diseases that were once considered incurable are now treatable, lessening the economic burden on the health care system and restoring patients’ quality of life. As evidenced by this report, advances in biopharmaceutical research make an enormous impact to both individuals and the larger community. To improve our health care system, we need policies that support a robust research and development ecosystem so we continue to see improvements in life expectancy thanks to innovation.

Learn more at letstalkaboutcost.org.

Gabby Migliara

Gabby Migliara is a director of Public Affairs at PhRMA focusing on internal communications and PhRMA’s digital presence, including maintaining this website and executive social presence. She previously worked with the U.S. Census Bureau on marketing and communications for the 2020 Census campaign. Outside the office, Gabby enjoys trying new restaurants, hanging with her cat and exploring D.C. neighborhoods.

New study: HPV vaccination helps prevent cervical cancer deaths

July 21, 2026

America's cancer research progress is real and worth protecting

May 28, 2026

Ahead of ASCO: Cancer innovation is promising, but policy choices matter

May 26, 2026

Advancing patient care: A look at new medicines approved in 2025

January 30, 2026

CAREs 2025: Supporting community-based solutions that improve access to medicines

January 22, 2026

New analysis finds 340B hospitals push patients toward costly care to boost profits

January 21, 2026

Price setting policies put cancer gains in jeopardy

January 16, 2026

Improved treatments continue to lead to declining cancer mortality rates in the U.S.

February 25, 2025

Guest Perspective: Prioritize Innovative Care

February 11, 2025

Preventing and fighting disease: A look at the biopharmaceutical progress made for patients in 2024

February 3, 2025

Post-approval R&D is critical for fighting cancer. The IRA makes it more difficult.

November 13, 2024

The importance of partnership: A conversation with Takeda

October 10, 2024

Three things to know about the United Nations’ new HIV/AIDS report

July 31, 2024

The future of oncology R&D lies in policymakers’ hands

July 8, 2024

Showcasing the promise of biopharma at ASCO 2024

June 28, 2024

Championing cancer equity: Our drive for healthier AANHPI communities

May 1, 2024

The impact of innovative medicines: A caregiver's perspective

March 26, 2024

PhRMA awards $250,000 to community-based projects to improve equitable cancer outcomes

February 9, 2024

Three things to know about antibody drug conjugates

February 2, 2024

Watch: Putting patients front and center for World AIDS Day

November 30, 2023

The IRA’s pill penalty threatens the future of oncology R&D

November 16, 2023

New Report: 1,600 cancer treatments and vaccines in clinical development

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R&D leaders to Biden Administration: Your policies are undermining the Cancer Moonshot

October 18, 2023

Watch: New video series spotlights advances in biopharmaceutical science

August 24, 2023

Between hope and despair: Improving cancer outcomes

July 11, 2023

New report shows high-impact R&D happens after cancer medicines are first approved

July 10, 2023

New report shows how the Inflation Reduction Act stifles innovation for small molecule medicines

June 22, 2023

ASCO 2023: Protecting our progress in the fight against cancer

June 15, 2023

Highlights from ASCO 2023

June 8, 2023

IRA Impacts: Cancer treatment research and development

March 23, 2023

State policymakers can protect American innovation and help Americans live longer, healthier lives

February 9, 2023

ICYMI: Cancer death rate continues to decline due to treatment advances

January 25, 2023

Novel medicines approved in 2022 offer increased treatment options for patients

January 23, 2023

Stories from the lab: Researchers discuss innovative treatments for cancers of the blood

December 1, 2022

ICYMI: PhRMA COO Lori Reilly Esq. speaks with Jacob Van Naarden about the future of cancer research

November 8, 2022

Protecting treatment advances for breast cancer

October 31, 2022

Making coupons count for patients with HIV

August 8, 2022

Key takeaways from ASCO's annual meeting

June 10, 2022

ICYMI: First pediatric patient to receive CAR-T cell therapy celebrates 10 years of being cancer-free

May 25, 2022

Report: More than 500 medicines in development to treat disorders of the blood

May 18, 2022

4 things to know about biopharmaceutical efforts to fight cancer

February 24, 2022

New data show continued decline in death rates for cancer patients related to treatment advances

January 20, 2022

World AIDS Day: Remembering those we’ve lost and exploring the continued fight against HIV/AIDS

December 1, 2021

Recognizing National Immunization Awareness Month

August 31, 2021

New data from insurers show detriments of copay accumulator adjustment programs

April 28, 2021

Nearly 40% of commercially insured patients face half their annual out-of-pocket expenses from just one health care encounter

March 2, 2021

Action needed to preserve the six protected classes

February 3, 2021

Insurers shift medicine costs to patients with severe chronic illnesses

February 1, 2021

The new Administration should reconsider a recent HHS rule that could negatively impact patient access and affordability

January 27, 2021

New insulin report highlights how incentives benefit middlemen, harm patients

January 22, 2021

ICYMI: Cancer death rate continues decline due to advances in treatment

January 19, 2021

New data show retail medicine prices fell in 2019

January 13, 2021

Report: More than 1,300 medicines and vaccines in development to help fight cancer

December 15, 2020

Fact Check: How hospitals continue to drive health care spending

December 3, 2020

Accumulator adjustment programs lead to surprise out-of-pocket costs and nonadherence, analysis finds

November 19, 2020

Survey found insurance premiums grew faster than inflation in 2020

October 20, 2020

Proposed change to Medicaid line extension definition ignores importance of critical improvements in treatments

October 13, 2020

Study finds middlemen excluded nearly 850 medicines from formularies this year

September 17, 2020

Manufacturer cost-sharing assistance programs can save chronically ill patients hundreds to thousands of dollars annually

August 19, 2020

Commercial health plans have increased patients’ out-of-pocket costs by over 50% in some therapeutic areas

August 12, 2020

Commercial health plans transition from copays to coinsurance and deductibles has increased patient out-of-pocket costs

August 6, 2020

Four things to know about the IQVIA “Medicine Spending and Affordability in the U.S.” report

August 5, 2020

New data show commercially insured patients face increasingly high cost sharing for brand medicines

July 30, 2020

Payers subject 80% of new RA and MS patients to utilization management restrictions

July 22, 2020

New report explores setbacks that bring future cancer success stories

July 16, 2020

Study finds the pharmaceutical industry retains a smaller share of revenue than research-intensive industries

July 14, 2020

Guest Post: Takeda seeks ‘new normal’ for cancer research during the COVID-19 pandemic

June 24, 2020

ICYMI: Pharmacy benefit managers increasingly exclude medicines from formularies, restricting patient access

June 1, 2020

New rule makes it harder for patients to lower their out-of-pocket costs

May 20, 2020

ICYMI: Patients saved nearly $800,000 out of pocket through innovative contracting arrangements

April 20, 2020

Retail medicine spending to remain stable share of overall health care spending through next decade

April 16, 2020

PhRMA comments on HHS proposed rule on manufacturer cost-sharing assistance and accumulator adjustment programs

March 3, 2020

Addressing barriers that inhibit value-based contracts

February 21, 2020

Fact Check: HCCI analysis overstates medicine spending and prices

February 19, 2020

Cancer medicines cost twice as much at hospitals, study finds

January 21, 2020

Nearly 50% of brand medicine spending goes to the supply chain and others

January 9, 2020

New NHE data: Medicine prices declined, and hospitals were biggest driver of health care spending in 2018

December 6, 2019

More evidence that medicine prices are growing at slowest rate in decades

October 4, 2019

The truth about the marketing and promotion of medicines

October 3, 2019

Survey shows out-of-pocket costs top health care concern for voters

October 2, 2019

Hospitals make 9 times more than physicians’ offices on provider-administered medicines

September 10, 2019

Three things to know about the Part D GAO report

August 16, 2019

Four states adopt first-in-the-nation laws to protect patients from surprise insurer practices

July 15, 2019

New Let’s Talk About Cost TV ad asks: Why aren’t patients sharing in savings at the pharmacy counter?

July 9, 2019

Study finds hospitals continue to mark up medicines up to 500% of their cost

July 9, 2019

Three reasons why the latest Rx Savings Solutions analysis is misleading

July 2, 2019

How the rebate rule would help reduce patients’ out-of-pocket costs

June 3, 2019

New study finds hospitals continue to push patients to costlier outpatient settings

May 13, 2019

4 Things to know about the IQVIA “Medicine Use and Spending” report

May 9, 2019

Six policy solutions to help patients afford their insulin

April 9, 2019

PhRMA comments on OIG proposed rule to reform the rebate system

April 8, 2019

340B continues to drive shift in site of care for physician-administered medicines to more expensive hospital settings

April 5, 2019

Five key facts about the market for insulins

April 1, 2019

OIG proposed rule could help strengthen the Part D market

March 28, 2019

Rebate rule would help ensure seniors with diabetes don’t pay more for their medicine than their insurer

March 25, 2019

The PBM story you haven’t heard: Hidden fees quadrupled in two years

March 20, 2019

OptumRX: Sharing rebates with patients is “worth it”

March 18, 2019

Changes to the six protected class policy are the wrong prescription for Medicare and HIV patients

March 15, 2019

New data show how sharing negotiated discounts could save certain patients hundreds of dollars at the pharmacy counter

February 25, 2019

What you need to know about the new NHE health spending projections

February 22, 2019

New study shows why insurers should share rebates with Medicare Part D beneficiaries on a mandatory basis

February 14, 2019

New IQVIA data show medicine prices grew just 1.5 percent in 2018

January 29, 2019

Health Affairs study misses the mark on medicine costs

January 28, 2019

New government data show medicine price growth continues to decline

January 18, 2019

10 things you should know about medicine spending and costs

January 2, 2019

Six key facts about the market for insulins

December 17, 2018

World AIDS Day 2018: Hope for the future

December 1, 2018

Americans want to know more than just the list price of a medicine—and we’re answering their call

October 15, 2018

What they are saying: PhRMA member executives on industry’s new approach to DTC television advertising

October 15, 2018

Coupons allow patients to remain on medicines in spite of high cost sharing and deductibles

October 4, 2018

Saving kids and dogs from shared cancers

September 17, 2018

New study finds some hospitals mark up medicine prices at least 700 percent

September 5, 2018

69 percent of patients abandon medicines when cost sharing is more than $250

August 23, 2018

New analysis in Health Affairs reinforces one-third of medicine list price rebated back to supply chain

August 13, 2018

PhRMA submission to HHS on blueprint to lower drug prices and reduce out-of-pocket costs

July 16, 2018

New data show patients’ out-of-pocket costs are rising faster than their insurers’ costs

July 9, 2018

Pass-through rebates do not violate non-interference clause but they do increase savings for seniors

July 2, 2018

Guest post: Excellent care for LGBTQ patients requires cultural humility and specific medical knowledge

June 28, 2018

Patients with a deductible have seen their out-of-pocket costs for brand medicines increase 50 percent since 2014

June 20, 2018

ICYMI: Analysis finds higher outpatient drug spending at 340B hospitals

June 18, 2018

Diversity of thought fuels next generation of breakthroughs

June 7, 2018

New analysis shows that more medicines worldwide are available to U.S. patients

June 5, 2018

New analysis shows that HTA organizations may frequently restrict access to cancer treatments

June 1, 2018

New report and resources put cancer in context, showing more than 1,100 medicines and vaccines in development

May 30, 2018

Sharing negotiated discounts at the pharmacy counter could save seniors with diabetes more than $350 annually

May 17, 2018

Video: PhRMA CEO discusses biopharmaceutical supply chain at POLITICO event

May 4, 2018

Event tomorrow: Making the biopharmaceutical supply chain work for patients

May 2, 2018

Spending on medicines grew less than one percent in 2017

April 19, 2018

Patients pay the price when hospitals mark up cancer medicines

April 5, 2018

New Let’s Talk About Cost ads highlight how copay accumulator programs could leave patients financially exposed

March 27, 2018

Video: How does the supply chain shape brand-name medicine prices?

March 19, 2018

4 Things to know about the IQVIA 2018 and Beyond: Outlook and Turning Points report

March 13, 2018

ICYMI: Two PBM reports show dramatic slowdown in medicine spending growth

March 2, 2018

Copay coupons can help ease patients’ out-of-pocket costs

February 16, 2018

PhRMA launches new consumer-facing Let’s Talk About Cost website

January 24, 2018

NHE Data: Medicine spending grew just 1.3 percent in 2016

December 12, 2017

World AIDS Day 2017: Scientific breakthroughs paving the way for an AIDS-free generation

December 1, 2017

A new era in cancer

November 1, 2017

PhRMA, member companies and NIH create public-private partnership for immuno-oncology

October 12, 2017

4 things to know about the QuintilesIMS drivers of medicine spending in the U.S. report

September 28, 2017

What they are saying: Study on cancer R&D costs is not an accurate representation of marketplace

September 12, 2017

Protect your health: Important disaster preparedness tips for Harvey and Irma

September 6, 2017

Video: PhRMA CEO discusses medicine costs with CNBC's Squawk Box

July 31, 2017

More than 50 medicines and vaccines in development for HIV infection, treatment and prevention

June 27, 2017

Medicare Monday: New report highlights progress in fighting cancer with new physician-administered medicines

June 12, 2017

More than 240 immuno-oncology treatments in development to fight cancer

June 1, 2017

Medicines have significantly increased chances of cancer survival around the globe

May 24, 2017

ICYMI: New study shows medicines advance life expectancy for HIV patients

May 15, 2017

ICYMI: Report highlights overall decrease in cancer death rates

April 3, 2017

New analysis: More than half of patients’ out-of-pocket spending for brand medicines is based on full list price

March 29, 2017

Biopharmaceutical industry’s success reducing disparities for African Americans

February 16, 2017

This is not a video game: New TV ad showcases the destruction of a cancer cell by immune system

February 5, 2017

The 20-year journey yielding a new weapon against cancer

January 10, 2017

Significant progress fighting cancer: Death rate has dropped 25 percent

January 9, 2017

Study finds biopharmaceutical innovation is responsible for 35% of the increase in life expectancy from 1990 to 2015

Cancer

HIVAIDS

Lets Talk About Cost

Study finds biopharmaceutical innovation is responsible for 35% of the increase in life expectancy from 1990 to 2015

October 21, 2020

Study finds biopharmaceutical innovation is responsible for 35% of the increase in life expectancy from 1990 to 2015

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