The Moran Company conducted an analysis of the 2022 Medicare Part B Quarterly Average Sales Price (ASP) Pricing File published by the Centers for Medicare and Medicaid Services (CMS), which contains the payment amounts used to pay for Part B covered medicines and biologics. The analysis includes the top 50 Part B medicines by total spending in 2020 that have ASP data in 2022. The purpose of this analysis was to replicate the CMS analysis of the trend in ASPs in the file and to determine the drivers of reductions in ASP.