Over the last half-century, new medicines, technologies and biopharmaceutical research have revolutionized health care and helped millions of patients live longer, healthier lives. Building on this progress, America now is on the cusp of a golden era of biopharmaceutical discovery and personalized medicine. But certain actions must be taken at the policy level to ensure that the marketplace evolves at the pace of scientific advances and that patient needs and preferences are kept central. These policy solutions represent a commitment to a stronger U.S. health care market and to our future health system as a whole.