Drug shortages can occur for a variety of reasons and at a variety of points throughout the prescription drug supply chain. This can include manufacturing quality issues, production delays or possible delays in receiving raw materials and other components from suppliers. Disruptions from natural disasters and or public health emergencies also contribute. Beyond these core factors, workforce challenges, manufacturing infrastructure and policies in the Inflation Reduction Act could increase drug shortages. Generic drugs are particularly susceptible to drug shortages due to persistent economic challenges facing the generic industry.